Names & Taxonomy
- Uniprot ID:
- P36268
- Entry Name:
- GGT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Inactive gamma-glutamyltranspeptidase 2 (GGT 2) (Gamma-glutamyltransferase 2) (Glutathione hydrolase 2)
- Gene Names:
- GGT2
- Gene Names Primary:
- GGT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 569
- Sequence:
- MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAMAADAKQCLEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGVGLFLTIYNSTTGKAEVINAREVAPRLAFASMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAVLENKRTVIEQQPVLWYVFCRDRKVLREGERLTLPRLADTYEMLAIEGAQAFYNGSLMAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDAVLYMPSARLSGPVLALILNILKGYNFSRESVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVCSPVSGILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGGTQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, perinuclear region
Function
- Function:
- Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer.
- Active Site:
- ACT_SITE 381 381 Nucleophile.
- Gene Ontology Go:
- anchored component of external side of plasma membrane
endoplasmic reticulum
extracellular exosome
perinuclear region of cytoplasm
plasma membrane
gamma-glutamyltransferase activity
glutathione biosynthetic process
glutathione derivative biosynthetic process
glutathione metabolic process
leukotriene biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- glutathione biosynthetic process
glutathione derivative biosynthetic process
glutathione metabolic process
leukotriene biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- gamma-glutamyltransferase activity
- Gene Ontology Cellular Component:
- anchored component of external side of plasma membrane
endoplasmic reticulum
extracellular exosome
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasm
Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal