Names & Taxonomy
- Uniprot ID:
- P35754
- Entry Name:
- GLRX1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutaredoxin-1 (Thioltransferase-1) (TTase-1)
- Gene Names:
- GLRX GRX
- Gene Names Primary:
- GLRX
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 106
- Sequence:
- MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytosol
extracellular exosome
mitochondrion
nucleus
electron carrier activity
glutathione disulfide oxidoreductase activity
glutathione oxidoreductase activity
protein N-terminus binding
cell redox homeostasis
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
positive regulation of membrane potential
positive regulation of sodium ion transmembrane transporter activity
protein deglutathionylation
small molecule metabolic process - Gene Ontology Biological Process:
- cell redox homeostasis
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
positive regulation of membrane potential
positive regulation of sodium ion transmembrane transporter activity
protein deglutathionylation
small molecule metabolic process - Gene Ontology Molecular Function:
- electron carrier activity
glutathione disulfide oxidoreductase activity
glutathione oxidoreductase activity
protein N-terminus binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
mitochondrion
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Electron transport
Polymorphism
Redox-active center
Reference proteome
Transport