Names & Taxonomy
- Uniprot ID:
- P35503
- Entry Name:
- UD13_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-3 (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A3)
- Gene Names:
- UGT1A3 GNT1 UGT1
- Gene Names Primary:
- UGT1A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 534
- Sequence:
- MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome. Endoplasmic reticulum membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB06403 DB01076 DB00796 DB00434 DB06210 DB00749 DB00973 DB04953 DB01544 DB00712 DB01095 DB01050 DB01029 DB00555 DB00678 DB00227 DB01252 DB00295 DB08860 DB00641 DB00313
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
xenobiotic glucuronidation - Gene Ontology Biological Process:
- cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
xenobiotic glucuronidation - Gene Ontology Molecular Function:
- enzyme binding
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
retinoic acid binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix