Names & Taxonomy

Uniprot ID:
P35498
Entry Name:
SCN1A_HUMAN
Status:
reviewed
Protein Names:
Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)
Gene Names:
SCN1A NAC1 SCN1
Gene Names Primary:
SCN1A
Organism:
Homo sapiens (Human)

Structure

Length:
2009
Sequence:
MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Cross Reference Drug Bank:
DB04855 DB01595 DB04930 DB01121 DB01438 DB00252 DB00273 DB00313 DB00909
Gene Ontology Go:
axon initial segment
intercalated disc
neuronal cell body
node of Ranvier
plasma membrane
T-tubule
voltage-gated sodium channel complex
Z disc
sodium ion binding
voltage-gated sodium channel activity
adult walking behavior
membrane depolarization during action potential
neuromuscular process controlling posture
neuronal action potential
neuronal action potential propagation
positive regulation of defense response to virus by host
sodium ion transport
xenophagy
Gene Ontology Biological Process:
adult walking behavior
membrane depolarization during action potential
neuromuscular process controlling posture
neuronal action potential
neuronal action potential propagation
positive regulation of defense response to virus by host
sodium ion transport
xenophagy
Gene Ontology Molecular Function:
sodium ion binding
voltage-gated sodium channel activity
Gene Ontology Cellular Component:
axon initial segment
intercalated disc
neuronal cell body
node of Ranvier
plasma membrane
T-tubule
voltage-gated sodium channel complex
Z disc
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
10742094 15815621 8062593 1317301 21566136 11254444 11254445 11359211 11524484 11756608 12083760 12566275 12919402 12576172 12754708 14672992 12610651 12821740 14504318 12535936 14738421 15525788 15087100 16122630 15715999 16210358 16054936 15944908 16326807 15694566 17129991 17054684 17054685 16525050 16713920 16458823 17347258 17561957 17507202 17397047 17928445 17679682 18330841 18021921 17927801 18413471 18251839 18031552 18566737 18639757 19694741 19783390 19522081 19339291 18930999 19332696 19464195 20682179 20550552 20452746 20392657 20110217 20729507 20431604 19589774 20522430 20600615 19563458 20117752 21864321 21248271 22092154 22309220 22612257 23195492 26311622