Names & Taxonomy
- Uniprot ID:
- P35346
- Entry Name:
- SSR5_HUMAN
- Status:
- reviewed
- Protein Names:
- Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R)
- Gene Names:
- SSTR5
- Gene Names Primary:
- SSTR5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 364
- Sequence:
- MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
- Cross Reference Drug Bank:
- DB06791 DB00104 DB06663 DB04894
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
neuron projection
nucleus
plasma membrane
neuropeptide binding
somatostatin receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cellular response to glucocorticoid stimulus
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
glucose homeostasis
negative regulation of cell proliferation
positive regulation of cytokinesis
regulation of insulin secretion - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cellular response to glucocorticoid stimulus
glucose homeostasis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
positive regulation of cytokinesis
regulation of insulin secretion - Gene Ontology Molecular Function:
- neuropeptide binding
somatostatin receptor activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane
neuron projection
nucleus
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix