Names & Taxonomy
- Uniprot ID:
- P35237
- Entry Name:
- SPB6_HUMAN
- Status:
- reviewed
- Protein Names:
- Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)
- Gene Names:
- SERPINB6 PI6 PTI
- Gene Names Primary:
- SERPINB6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 376
- Sequence:
- MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
- Cross Reference Drug Bank:
- DB00055
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
extracellular space
protein complex
protease binding
serine-type endopeptidase inhibitor activity
cellular response to osmotic stress
negative regulation of endopeptidase activity
sensory perception of sound - Gene Ontology Biological Process:
- cellular response to osmotic stress
negative regulation of endopeptidase activity
sensory perception of sound - Gene Ontology Molecular Function:
- protease binding
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
extracellular space
protein complex - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Deafness
Direct protein sequencing
Non-syndromic deafness
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor