Names & Taxonomy

Uniprot ID:
P35237
Entry Name:
SPB6_HUMAN
Status:
reviewed
Protein Names:
Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)
Gene Names:
SERPINB6 PI6 PTI
Gene Names Primary:
SERPINB6
Organism:
Homo sapiens (Human)

Structure

Length:
376
Sequence:
MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Cross Reference Drug Bank:
DB00055
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
extracellular space
protein complex
protease binding
serine-type endopeptidase inhibitor activity
cellular response to osmotic stress
negative regulation of endopeptidase activity
sensory perception of sound
Gene Ontology Biological Process:
cellular response to osmotic stress
negative regulation of endopeptidase activity
sensory perception of sound
Gene Ontology Molecular Function:
protease binding
serine-type endopeptidase inhibitor activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
extracellular space
protein complex
Keywords:
Acetylation
Complete proteome
Cytoplasm
Deafness
Direct protein sequencing
Non-syndromic deafness
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor

Publication

PubMed ID:
8415716 8136380 14702039 17974005 14574404 15489334 8486644 10068683 14670919 17761692 18669648 20451170 21269460 22223895 24275569