Names & Taxonomy
- Uniprot ID:
- P34981
- Entry Name:
- TRFR_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)
- Gene Names:
- TRHR
- Gene Names Primary:
- TRHR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 398
- Sequence:
- MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
thyrotropin-releasing hormone receptor activity
G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- G-protein coupled receptor signaling pathway
- Gene Ontology Molecular Function:
- thyrotropin-releasing hormone receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix