Names & Taxonomy
- Uniprot ID:
- P34969
- Entry Name:
- 5HT7R_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7)
- Gene Names:
- HTR7
- Gene Names Primary:
- HTR7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 479
- Sequence:
- MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
- Cross Reference Drug Bank:
- DB06288 DB00321 DB00543 DB01238 DB06216 DB01200 DB00248 DB00477 DB00363 DB00988 DB00216 DB00751 DB01049 DB04946 DB00458 DB00408 DB08815 DB00934 DB00247 DB06148 DB00370 DB00334 DB01224 DB09068 DB00246
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled serotonin receptor activity
blood circulation
circadian rhythm
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
serotonin receptor signaling pathway
smooth muscle contraction
synaptic transmission
vasoconstriction - Gene Ontology Biological Process:
- blood circulation
circadian rhythm
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
serotonin receptor signaling pathway
smooth muscle contraction
synaptic transmission
vasoconstriction - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix