Names & Taxonomy
- Uniprot ID:
- P33681
- Entry Name:
- CD80_HUMAN
- Status:
- reviewed
- Protein Names:
- T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
- Gene Names:
- CD80 CD28LG CD28LG1 LAB7
- Gene Names Primary:
- CD80
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 288
- Sequence:
- MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- Cross Reference Drug Bank:
- DB01281 DB06681
- Gene Ontology Go:
- cell surface
external side of plasma membrane
integral component of membrane
intracellular
plasma membrane
coreceptor activity
virus receptor activity
cell-cell signaling
cellular response to lipopolysaccharide
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
intracellular signal transduction
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of alpha-beta T cell proliferation
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of signal transduction
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription, DNA-templated
T cell activation
T cell costimulation - Gene Ontology Biological Process:
- cell-cell signaling
cellular response to lipopolysaccharide
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
intracellular signal transduction
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of alpha-beta T cell proliferation
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of signal transduction
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription, DNA-templated
T cell activation
T cell costimulation - Gene Ontology Molecular Function:
- coreceptor activity
virus receptor activity - Gene Ontology Cellular Component:
- cell surface
external side of plasma membrane
integral component of membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Membrane
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9NZQ7; P16410; P08138