Names & Taxonomy
- Uniprot ID:
- P33121
- Entry Name:
- ACSL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2)
- Gene Names:
- ACSL1 FACL1 FACL2 LACS LACS1 LACS2
- Gene Names Primary:
- ACSL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 698
- Sequence:
- MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane
Function
- Function:
- Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.
- Catalytic Activity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cross Reference Drug Bank:
- DB00131 DB00171
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial outer membrane
mitochondrion
peroxisomal membrane
plasma membrane
ATP binding
long-chain fatty acid-CoA ligase activity
adiponectin-activated signaling pathway
alpha-linolenic acid metabolic process
cellular lipid metabolic process
linoleic acid metabolic process
lipid biosynthetic process
long-chain fatty acid import
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of protein serine/threonine kinase activity
response to drug
response to nutrient
response to oleic acid
response to organic cyclic compound
small molecule metabolic process
triglyceride biosynthetic process
unsaturated fatty acid metabolic process
xenobiotic catabolic process - Gene Ontology Biological Process:
- adiponectin-activated signaling pathway
alpha-linolenic acid metabolic process
cellular lipid metabolic process
linoleic acid metabolic process
lipid biosynthetic process
long-chain fatty acid import
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
positive regulation of protein serine/threonine kinase activity
response to drug
response to nutrient
response to oleic acid
response to organic cyclic compound
small molecule metabolic process
triglyceride biosynthetic process
unsaturated fatty acid metabolic process
xenobiotic catabolic process - Gene Ontology Molecular Function:
- ATP binding
long-chain fatty acid-CoA ligase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mitochondrial outer membrane
mitochondrion
peroxisomal membrane
plasma membrane - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Fatty acid metabolism
Glycoprotein
Ligase
Lipid metabolism
Magnesium
Membrane
Microsome
Mitochondrion
Mitochondrion outer membrane
Nitration
Nucleotide-binding
Peroxisome
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix