Names & Taxonomy

Uniprot ID:
P32249
Entry Name:
GP183_HUMAN
Status:
reviewed
Protein Names:
G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2)
Gene Names:
GPR183 EBI2
Gene Names Primary:
GPR183
Organism:
Homo sapiens (Human)

Structure

Length:
361
Sequence:
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
oxysterol binding
adaptive immune response
B cell activation involved in immune response
G-protein coupled receptor signaling pathway
humoral immune response
immune response
mature B cell differentiation involved in immune response
positive regulation of B cell proliferation
positive regulation of ERK1 and ERK2 cascade
Gene Ontology Biological Process:
adaptive immune response
B cell activation involved in immune response
G-protein coupled receptor signaling pathway
humoral immune response
immune response
mature B cell differentiation involved in immune response
positive regulation of B cell proliferation
positive regulation of ERK1 and ERK2 cascade
Gene Ontology Molecular Function:
G-protein coupled receptor activity
oxysterol binding
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Adaptive immunity
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8383238 14702039 15057823 15489334 16540462 21673108 21796212 18987736