Names & Taxonomy
- Uniprot ID:
- P32249
- Entry Name:
- GP183_HUMAN
- Status:
- reviewed
- Protein Names:
- G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2)
- Gene Names:
- GPR183 EBI2
- Gene Names Primary:
- GPR183
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 361
- Sequence:
- MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
oxysterol binding
adaptive immune response
B cell activation involved in immune response
G-protein coupled receptor signaling pathway
humoral immune response
immune response
mature B cell differentiation involved in immune response
positive regulation of B cell proliferation
positive regulation of ERK1 and ERK2 cascade - Gene Ontology Biological Process:
- adaptive immune response
B cell activation involved in immune response
G-protein coupled receptor signaling pathway
humoral immune response
immune response
mature B cell differentiation involved in immune response
positive regulation of B cell proliferation
positive regulation of ERK1 and ERK2 cascade - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
oxysterol binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Adaptive immunity
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Immunity
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix