Names & Taxonomy
- Uniprot ID:
- P32238
- Entry Name:
- CCKAR_HUMAN
- Status:
- reviewed
- Protein Names:
- Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)
- Gene Names:
- CCKAR CCKRA
- Gene Names Primary:
- CCKAR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 428
- Sequence:
- MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Cross Reference Drug Bank:
- DB00403
- Gene Ontology Go:
- cytosol
endoplasmic reticulum
endosome
integral component of plasma membrane
lysosome
plasma membrane
terminal bouton
cholecystokinin receptor activity
actin cytoskeleton reorganization
axonogenesis
cellular response to hormone stimulus
digestion
feeding behavior
forebrain development
gastric acid secretion
insulin secretion
neuron migration
organ regeneration
pancreas development
pancreatic juice secretion
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of somatostatin secretion
reduction of food intake in response to dietary excess
regulation of calcium ion transport
regulation of hormone secretion
regulation of potassium ion transport
response to glucocorticoid
response to heat
response to lipopolysaccharide
response to nutrient
response to radiation
response to starvation
temperature homeostasis - Gene Ontology Biological Process:
- actin cytoskeleton reorganization
axonogenesis
cellular response to hormone stimulus
digestion
feeding behavior
forebrain development
gastric acid secretion
insulin secretion
neuron migration
organ regeneration
pancreas development
pancreatic juice secretion
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of somatostatin secretion
reduction of food intake in response to dietary excess
regulation of calcium ion transport
regulation of hormone secretion
regulation of potassium ion transport
response to glucocorticoid
response to heat
response to lipopolysaccharide
response to nutrient
response to radiation
response to starvation
temperature homeostasis - Gene Ontology Molecular Function:
- cholecystokinin receptor activity
- Gene Ontology Cellular Component:
- cytosol
endoplasmic reticulum
endosome
integral component of plasma membrane
lysosome
plasma membrane
terminal bouton - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix