Names & Taxonomy
- Uniprot ID:
- P32119
- Entry Name:
- PRDX2_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)
- Gene Names:
- PRDX2 NKEFB TDPX1
- Gene Names Primary:
- PRDX2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 198
- Sequence:
- MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
- Catalytic Activity:
- 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
- Active Site:
- ACT_SITE 51 51 Cysteine sulfenic acid (-SOH) intermediate.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
antioxidant activity
thioredoxin peroxidase activity
cellular response to oxidative stress
gene expression
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of apoptotic process
removal of superoxide radicals
response to oxidative stress
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cellular response to oxidative stress
gene expression
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of apoptotic process
removal of superoxide radicals
response to oxidative stress
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- antioxidant activity
thioredoxin peroxidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Antioxidant
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Oxidoreductase
Peroxidase
Phosphoprotein
Polymorphism
Redox-active center
Reference proteome