Names & Taxonomy

Uniprot ID:
P32019
Entry Name:
I5P2_HUMAN
Status:
reviewed
Protein Names:
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Gene Names:
INPP5B OCRL2
Gene Names Primary:
INPP5B
Organism:
Homo sapiens (Human)

Structure

Length:
993
Sequence:
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
Catalytic Activity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Gene Ontology Go:
cytoplasm
cytosol
early endosome membrane
endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus
integral component of membrane
membrane
phagocytic vesicle membrane
plasma membrane
inositol-1,4,5-trisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
in utero embryonic development
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
regulation of protein processing
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
sperm motility
spermatogenesis
Gene Ontology Biological Process:
inositol phosphate metabolic process
in utero embryonic development
phosphatidylinositol dephosphorylation
regulation of protein processing
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
spermatogenesis
sperm motility
Gene Ontology Molecular Function:
inositol-1,4,5-trisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
early endosome membrane
endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus
integral component of membrane
membrane
phagocytic vesicle membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Golgi apparatus
Hydrolase
Lipoprotein
Magnesium
Membrane
Metal-binding
Methylation
Polymorphism
Prenylation
Reference proteome

Publication

PubMed ID:
7721860 16710414 15489334 17974005 1718960 17956944 20133602 21269460 21233288 25869668