Names & Taxonomy
- Uniprot ID:
- P32019
- Entry Name:
- I5P2_HUMAN
- Status:
- reviewed
- Protein Names:
- Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
- Gene Names:
- INPP5B OCRL2
- Gene Names Primary:
- INPP5B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 993
- Sequence:
- MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
- Catalytic Activity:
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
- Gene Ontology Go:
- cytoplasm
cytosol
early endosome membrane
endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus
integral component of membrane
membrane
phagocytic vesicle membrane
plasma membrane
inositol-1,4,5-trisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
in utero embryonic development
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
regulation of protein processing
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
sperm motility
spermatogenesis - Gene Ontology Biological Process:
- inositol phosphate metabolic process
in utero embryonic development
phosphatidylinositol dephosphorylation
regulation of protein processing
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
spermatogenesis
sperm motility - Gene Ontology Molecular Function:
- inositol-1,4,5-trisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
early endosome membrane
endoplasmic reticulum-Golgi intermediate compartment
Golgi apparatus
integral component of membrane
membrane
phagocytic vesicle membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Golgi apparatus
Hydrolase
Lipoprotein
Magnesium
Membrane
Metal-binding
Methylation
Polymorphism
Prenylation
Reference proteome