Names & Taxonomy
- Uniprot ID:
- P32004
- Entry Name:
- L1CAM_HUMAN
- Status:
- reviewed
- Protein Names:
- Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)
- Gene Names:
- L1CAM CAML1 MIC5
- Gene Names Primary:
- L1CAM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1257
- Sequence:
- MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.
- Gene Ontology Go:
- axonal growth cone
cell surface
focal adhesion
integral component of membrane
plasma membrane
axon guidance
blood coagulation
cell adhesion
chemotaxis
leukocyte migration
nervous system development
positive regulation of axon extension - Gene Ontology Biological Process:
- axon guidance
blood coagulation
cell adhesion
chemotaxis
leukocyte migration
nervous system development
positive regulation of axon extension - Gene Ontology Cellular Component:
- axonal growth cone
cell surface
focal adhesion
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hereditary spastic paraplegia
Hirschsprung disease
Immunoglobulin domain
Membrane
Mental retardation
Neurodegeneration
Neurogenesis
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 1932117 1769655 1627459 9286695 9479034 15772651 15489334 3136168 2387585 1923824 1993895 8592152 16335952 17081983 18669648 19159218 20068231 21269460 21406692 8401576 7881431 7920659 7920660 7762552 8556302 7562969 9118141 8929944 9268105 9300653 9195224 9521424 9452110 9744477 9832035 10797421 10805190 11857550 12435569 16650080 16816908 22344793