Names & Taxonomy
- Uniprot ID:
- P31994
- Entry Name:
- FCG2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
- Gene Names:
- FCGR2B CD32 FCG2 IGFR2
- Gene Names Primary:
- FCGR2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 310
- Sequence:
- MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISALPGYPECREMGETLPEKPANPTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00098 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- integral component of membrane
plasma membrane
immune response
regulation of immune response
signal transduction
viral process - Gene Ontology Biological Process:
- immune response
regulation of immune response
signal transduction
viral process - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Chromosomal rearrangement
Complete proteome
Disulfide bond
Glycoprotein
Host-virus interaction
IgG-binding protein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Systemic lupus erythematosus
Transmembrane
Transmembrane helix - Interacts With:
- P01857; Q92835; P16333; P19174; P29350