Names & Taxonomy

Uniprot ID:
P31939
Entry Name:
PUR9_HUMAN
Status:
reviewed
Protein Names:
Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]
Gene Names:
ATIC PURH OK/SW-cl.86
Gene Names Orf:
OK/SW-cl.86
Gene Names Primary:
ATIC
Organism:
Homo sapiens (Human)

Structure

Length:
592
Sequence:
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
Proteomes:
UP000005640

Function

Function:
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
Pathway:
Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.; Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
Catalytic Activity:
10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.; IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
Active Site:
ACT_SITE 137 137 Proton acceptor.
Cross Reference Drug Bank:
DB00563 DB00642 DB00116
Gene Ontology Go:
cytosol
extracellular exosome
membrane
mitochondrion
IMP cyclohydrolase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
protein homodimerization activity
'de novo' IMP biosynthetic process
brainstem development
cerebellum development
cerebral cortex development
dihydrofolate metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to inorganic substance
small molecule metabolic process
tetrahydrofolate biosynthetic process
Gene Ontology Biological Process:
'de novo' IMP biosynthetic process
brainstem development
cerebellum development
cerebral cortex development
dihydrofolate metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to inorganic substance
small molecule metabolic process
tetrahydrofolate biosynthetic process
Gene Ontology Molecular Function:
IMP cyclohydrolase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
protein homodimerization activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
membrane
mitochondrion
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Epilepsy
Hydrolase
Multifunctional enzyme
Polymorphism
Purine biosynthesis
Reference proteome
Transferase

Publication

PubMed ID:
8567683 8867801 9378707 14702039 15815621 15489334 1286667 19413330 19608861 21269460 22223895 22814378 24275569 25687571 14756553 14966129 15114530