Names & Taxonomy
- Uniprot ID:
- P31939
- Entry Name:
- PUR9_HUMAN
- Status:
- reviewed
- Protein Names:
- Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]
- Gene Names:
- ATIC PURH OK/SW-cl.86
- Gene Names Orf:
- OK/SW-cl.86
- Gene Names Primary:
- ATIC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 592
- Sequence:
- MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
- Proteomes:
- UP000005640
Function
- Function:
- Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
- Pathway:
- Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.; Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
- Catalytic Activity:
- 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.; IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
- Active Site:
- ACT_SITE 137 137 Proton acceptor.
- Cross Reference Drug Bank:
- DB00563 DB00642 DB00116
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
mitochondrion
IMP cyclohydrolase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
protein homodimerization activity
'de novo' IMP biosynthetic process
brainstem development
cerebellum development
cerebral cortex development
dihydrofolate metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to inorganic substance
small molecule metabolic process
tetrahydrofolate biosynthetic process - Gene Ontology Biological Process:
- 'de novo' IMP biosynthetic process
brainstem development
cerebellum development
cerebral cortex development
dihydrofolate metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to inorganic substance
small molecule metabolic process
tetrahydrofolate biosynthetic process - Gene Ontology Molecular Function:
- IMP cyclohydrolase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Epilepsy
Hydrolase
Multifunctional enzyme
Polymorphism
Purine biosynthesis
Reference proteome
Transferase