Names & Taxonomy

Uniprot ID:
P31641
Entry Name:
SC6A6_HUMAN
Status:
reviewed
Protein Names:
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)
Gene Names:
SLC6A6
Gene Names Primary:
SLC6A6
Organism:
Homo sapiens (Human)

Structure

Length:
620
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
plasma membrane
neurotransmitter:sodium symporter activity
taurine:sodium symporter activity
amino acid transmembrane transport
amino acid transport
cellular amino acid metabolic process
ion transport
taurine transport
transmembrane transport
transport
Gene Ontology Biological Process:
amino acid transmembrane transport
amino acid transport
cellular amino acid metabolic process
ion transport
taurine transport
transmembrane transport
transport
Gene Ontology Molecular Function:
neurotransmitter:sodium symporter activity
taurine:sodium symporter activity
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8382624 8010975 8654117 16641997 15489334 19349973