Names & Taxonomy
- Uniprot ID:
- P31153
- Entry Name:
- METK2_HUMAN
- Status:
- reviewed
- Protein Names:
- S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
- Gene Names:
- MAT2A AMS2 MATA2
- Gene Names Primary:
- MAT2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 395
- Sequence:
- MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
- Pathway:
- Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
- Catalytic Activity:
- ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cross Reference Drug Bank:
- DB00134 DB00118
- Gene Ontology Go:
- cytosol
methionine adenosyltransferase complex
ATP binding
metal ion binding
methionine adenosyltransferase activity
methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- methylation
one-carbon metabolic process
S-adenosylmethionine biosynthetic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- ATP binding
metal ion binding
methionine adenosyltransferase activity - Gene Ontology Cellular Component:
- cytosol
methionine adenosyltransferase complex - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Cobalt
Complete proteome
Magnesium
Metal-binding
Nucleotide-binding
One-carbon metabolism
Phosphoprotein
Potassium
Reference proteome
Transferase - Interacts With:
- Q9NZL9