Names & Taxonomy
- Uniprot ID:
- P30876
- Entry Name:
- RPB2_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)
- Gene Names:
- POLR2B
- Gene Names Primary:
- POLR2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1174
- Sequence:
- MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).
- Catalytic Activity:
- Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- Gene Ontology Go:
- DNA-directed RNA polymerase II, core complex
membrane
nucleoplasm
nucleus
chromatin binding
DNA binding
DNA-directed RNA polymerase activity
metal ion binding
poly(A) RNA binding
ribonucleoside binding
7-methylguanosine mRNA capping
DNA repair
gene expression
gene silencing by RNA
mRNA splicing, via spliceosome
nucleotide-excision repair
piRNA metabolic process
positive regulation of viral transcription
RNA splicing
somatic stem cell population maintenance
transcription elongation from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription-coupled nucleotide-excision repair
viral process - Gene Ontology Biological Process:
- 7-methylguanosine mRNA capping
DNA repair
gene expression
gene silencing by RNA
mRNA splicing, via spliceosome
nucleotide-excision repair
piRNA metabolic process
positive regulation of viral transcription
RNA splicing
somatic stem cell population maintenance
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
viral process - Gene Ontology Molecular Function:
- chromatin binding
DNA binding
DNA-directed RNA polymerase activity
metal ion binding
poly(A) RNA binding
ribonucleoside binding - Gene Ontology Cellular Component:
- DNA-directed RNA polymerase II, core complex
membrane
nucleoplasm
nucleus - Keywords:
- Complete proteome
DNA-directed RNA polymerase
Magnesium
Metal-binding
Nucleotidyltransferase
Nucleus
Reference proteome
Transcription
Transferase
Zinc
Zinc-finger