Names & Taxonomy

Uniprot ID:
P30837
Entry Name:
AL1B1_HUMAN
Status:
reviewed
Protein Names:
Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)
Gene Names:
ALDH1B1 ALDH5 ALDHX
Gene Names Primary:
ALDH1B1
Organism:
Homo sapiens (Human)

Structure

Length:
517
Sequence:
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Pathway:
Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Catalytic Activity:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Active Site:
ACT_SITE 285 285 Proton acceptor.
Gene Ontology Go:
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleoplasm
aldehyde dehydrogenase (NAD) activity
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
aldehyde dehydrogenase (NAD) activity
Gene Ontology Cellular Component:
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleoplasm
Keywords:
Acetylation
Complete proteome
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
2061311 14702039 15164053 15489334 21269460 24275569 25944712 8244338