Names & Taxonomy
- Uniprot ID:
- P30837
- Entry Name:
- AL1B1_HUMAN
- Status:
- reviewed
- Protein Names:
- Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)
- Gene Names:
- ALDH1B1 ALDH5 ALDHX
- Gene Names Primary:
- ALDH1B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
- Pathway:
- Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
- Catalytic Activity:
- An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
- Active Site:
- ACT_SITE 285 285 Proton acceptor.
- Gene Ontology Go:
- intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleoplasm
aldehyde dehydrogenase (NAD) activity
carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
ethanol catabolic process
ethanol oxidation
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aldehyde dehydrogenase (NAD) activity
- Gene Ontology Cellular Component:
- intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleoplasm - Keywords:
- Acetylation
Complete proteome
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide