Names & Taxonomy
- Uniprot ID:
- P30613
- Entry Name:
- KPYR_HUMAN
- Status:
- reviewed
- Protein Names:
- Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)
- Gene Names:
- PKLR PK1 PKL
- Gene Names Primary:
- PKLR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 574
- Sequence:
- MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
- Proteomes:
- UP000005640
Function
- Function:
- Plays a key role in glycolysis.
- Pathway:
- Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
- Catalytic Activity:
- ATP + pyruvate = ADP + phosphoenolpyruvate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by fructose 1,6-bisphosphate.
- Cross Reference Drug Bank:
- DB00119
- Gene Ontology Go:
- cytosol
extracellular exosome
ATP binding
kinase activity
magnesium ion binding
potassium ion binding
pyruvate kinase activity
ATP biosynthetic process
canonical glycolysis
carbohydrate metabolic process
cellular response to insulin stimulus
endocrine pancreas development
energy reserve metabolic process
glucose metabolic process
positive regulation of cellular metabolic process
pyruvate biosynthetic process
response to ATP
response to cAMP
response to glucose
response to heat
response to hypoxia
response to lithium ion
response to nutrient
small molecule metabolic process - Gene Ontology Biological Process:
- ATP biosynthetic process
canonical glycolysis
carbohydrate metabolic process
cellular response to insulin stimulus
endocrine pancreas development
energy reserve metabolic process
glucose metabolic process
positive regulation of cellular metabolic process
pyruvate biosynthetic process
response to ATP
response to cAMP
response to glucose
response to heat
response to hypoxia
response to lithium ion
response to nutrient
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
kinase activity
magnesium ion binding
potassium ion binding
pyruvate kinase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Disease mutation
Glycolysis
Hereditary hemolytic anemia
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Pyruvate
Reference proteome
Transferase