Names & Taxonomy
- Uniprot ID:
- P30531
- Entry Name:
- SC6A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
- Gene Names:
- SLC6A1 GABATR GABT1 GAT1
- Gene Names Primary:
- SLC6A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 599
- Sequence:
- MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity).
Function
- Function:
- Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
- Cross Reference Drug Bank:
- DB00349 DB00906
- Gene Ontology Go:
- axon
cell surface
integral component of membrane
integral component of plasma membrane
membrane
neuron projection
plasma membrane
presynapse
gamma-aminobutyric acid:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity
gamma-aminobutyric acid import
gamma-aminobutyric acid transport
learning
mitophagy in response to mitochondrial depolarization
negative regulation of synaptic transmission, GABAergic
neurotransmitter secretion
neurotransmitter transport
positive regulation of gamma-aminobutyric acid secretion
protein homooligomerization
response to calcium ion
response to cocaine
response to estradiol
response to lead ion
response to purine-containing compound
response to sucrose
response to toxic substance
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- gamma-aminobutyric acid import
gamma-aminobutyric acid transport
learning
mitophagy in response to mitochondrial depolarization
negative regulation of synaptic transmission, GABAergic
neurotransmitter secretion
neurotransmitter transport
positive regulation of gamma-aminobutyric acid secretion
protein homooligomerization
response to calcium ion
response to cocaine
response to estradiol
response to lead ion
response to purine-containing compound
response to sucrose
response to toxic substance
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- gamma-aminobutyric acid:sodium symporter activity
metal ion binding
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- axon
cell surface
integral component of membrane
integral component of plasma membrane
membrane
neuron projection
plasma membrane
presynapse - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Membrane
Metal-binding
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport