Names & Taxonomy
- Uniprot ID:
- P30520
- Entry Name:
- PURA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)
- Gene Names:
- ADSS ADSS2
- Gene Names Primary:
- ADSS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 456
- Sequence:
- MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Partially associated with particulate fractions.
Function
- Function:
- Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
- Pathway:
- Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.
- Catalytic Activity:
- GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 40 40 Proton acceptor.
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
plasma membrane
adenylosuccinate synthase activity
GTP binding
magnesium ion binding
phosphate ion binding
'de novo' AMP biosynthetic process
AMP biosynthetic process
aspartate metabolic process
cellular response to electrical stimulus
immune system process
IMP metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to ammonium ion
response to purine-containing compound
small molecule metabolic process - Gene Ontology Biological Process:
- 'de novo' AMP biosynthetic process
AMP biosynthetic process
aspartate metabolic process
cellular response to electrical stimulus
immune system process
IMP metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to ammonium ion
response to purine-containing compound
small molecule metabolic process - Gene Ontology Molecular Function:
- adenylosuccinate synthase activity
GTP binding
magnesium ion binding
phosphate ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Polymorphism
Purine biosynthesis
Reference proteome - Interacts With:
- Q8NB12