Names & Taxonomy
- Uniprot ID:
- P30518
- Entry Name:
- V2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)
- Gene Names:
- AVPR2 ADHR DIR DIR3 V2R
- Gene Names Primary:
- AVPR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 371
- Sequence:
- MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.
- Cross Reference Drug Bank:
- DB00872 DB00035 DB02638 DB06212 DB00067
- Gene Ontology Go:
- endoplasmic reticulum
endosome
Golgi apparatus
integral component of membrane
integral component of plasma membrane
plasma membrane
peptide binding
vasopressin receptor activity
activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cellular response to hormone stimulus
excretion
hemostasis
I-kappaB kinase/NF-kappaB signaling
interferon-gamma production
negative regulation of renal sodium excretion
negative regulation of urine volume
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of protein ubiquitination
positive regulation of systemic arterial blood pressure
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
renal water homeostasis
response to cytokine
response to peptide
telencephalon development
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
cellular response to hormone stimulus
excretion
hemostasis
I-kappaB kinase/NF-kappaB signaling
interferon-gamma production
negative regulation of renal sodium excretion
negative regulation of urine volume
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of protein ubiquitination
positive regulation of systemic arterial blood pressure
positive regulation of vasoconstriction
regulation of systemic arterial blood pressure by vasopressin
renal water homeostasis
response to cytokine
response to peptide
telencephalon development
transmembrane transport
water transport - Gene Ontology Molecular Function:
- peptide binding
vasopressin receptor activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endosome
Golgi apparatus
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Diabetes insipidus
Disease mutation
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Publication
- PubMed ID:
- 1415251 1534149 7913579 8735975 9581826 19440390 15489334 8882880 9224808 23236378 1356229 1303271 1303257 8267567 8479490 8514744 8037205 7999078 7987330 7833930 8045948 7984150 8078903 7560098 9402087 9452109 10694923 9711877 10770218 11026555 11232028 11916004 15872203 16845277 16959974