Names & Taxonomy

Uniprot ID:
P30305
Entry Name:
MPIP2_HUMAN
Status:
reviewed
Protein Names:
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Gene Names:
CDC25B CDC25HU2
Gene Names Primary:
CDC25B
Organism:
Homo sapiens (Human)

Structure

Length:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Function

Function:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Catalytic Activity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Enzyme Regulation:
ENZYME REGULATION: Stimulated by B-type cyclins.
Active Site:
ACT_SITE 487 487
Gene Ontology Go:
centrosome
cytoplasm
cytosol
nucleoplasm
spindle pole
protein kinase binding
protein tyrosine phosphatase activity
cell division
female meiosis I
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic nuclear division
oocyte maturation
peptidyl-tyrosine dephosphorylation
positive regulation of cell proliferation
positive regulation of cytokinesis
positive regulation of mitotic cell cycle
positive regulation of protein kinase activity
protein phosphorylation
Gene Ontology Biological Process:
cell division
female meiosis I
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic nuclear division
oocyte maturation
peptidyl-tyrosine dephosphorylation
positive regulation of cell proliferation
positive regulation of cytokinesis
positive regulation of mitotic cell cycle
positive regulation of protein kinase activity
protein phosphorylation
Gene Ontology Molecular Function:
protein kinase binding
protein tyrosine phosphatase activity
Gene Ontology Cellular Component:
centrosome
cytoplasm
cytosol
nucleoplasm
spindle pole
Keywords:
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Hydrolase
Mitosis
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome
Interacts With:
P31946; Q04917; P63104

Publication

PubMed ID:
1836978 1662986 9188863 11780052 15489334 11333986 12400006 15150265 15128871 15311285 15908796 15629715 17332740 18669648 19690332 21406692 10543950