Names & Taxonomy
- Uniprot ID:
- P30305
- Entry Name:
- MPIP2_HUMAN
- Status:
- reviewed
- Protein Names:
- M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
- Gene Names:
- CDC25B CDC25HU2
- Gene Names Primary:
- CDC25B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 580
- Sequence:
- MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
- Function:
- Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
- Catalytic Activity:
- Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Stimulated by B-type cyclins.
- Active Site:
- ACT_SITE 487 487
- Gene Ontology Go:
- centrosome
cytoplasm
cytosol
nucleoplasm
spindle pole
protein kinase binding
protein tyrosine phosphatase activity
cell division
female meiosis I
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic nuclear division
oocyte maturation
peptidyl-tyrosine dephosphorylation
positive regulation of cell proliferation
positive regulation of cytokinesis
positive regulation of mitotic cell cycle
positive regulation of protein kinase activity
protein phosphorylation - Gene Ontology Biological Process:
- cell division
female meiosis I
G2/M transition of mitotic cell cycle
mitotic cell cycle
mitotic nuclear division
oocyte maturation
peptidyl-tyrosine dephosphorylation
positive regulation of cell proliferation
positive regulation of cytokinesis
positive regulation of mitotic cell cycle
positive regulation of protein kinase activity
protein phosphorylation - Gene Ontology Molecular Function:
- protein kinase binding
protein tyrosine phosphatase activity - Gene Ontology Cellular Component:
- centrosome
cytoplasm
cytosol
nucleoplasm
spindle pole - Keywords:
- 3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Hydrolase
Mitosis
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome - Interacts With:
- P31946; Q04917; P63104