Names & Taxonomy
- Uniprot ID:
- P30085
- Entry Name:
- KCY_HUMAN
- Status:
- reviewed
- Protein Names:
- UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)
- Gene Names:
- CMPK1 CMK CMPK UCK UMK UMPK
- Gene Names Primary:
- CMPK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 196
- Sequence:
- MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKSVDEVFDEVVQIFDKEG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
- Catalytic Activity:
- ATP + (d)CMP = ADP + (d)CDP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 1 Mg(2+) ion per monomer.;
- Cross Reference Drug Bank:
- DB00441 DB00709
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleus
ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity
uridine kinase activity
uridylate kinase activity
'de novo' pyrimidine nucleobase biosynthetic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
pyrimidine ribonucleotide biosynthetic process
small molecule metabolic process
UMP biosynthetic process - Gene Ontology Biological Process:
- 'de novo' pyrimidine nucleobase biosynthetic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
pyrimidine ribonucleotide biosynthetic process
small molecule metabolic process
UMP biosynthetic process - Gene Ontology Molecular Function:
- ATP binding
cytidylate kinase activity
nucleoside diphosphate kinase activity
uridine kinase activity
uridylate kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Pyrimidine biosynthesis
Reference proteome
Transferase