Names & Taxonomy
- Uniprot ID:
- P30044
- Entry Name:
- PRDX5_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)
- Gene Names:
- PRDX5 ACR1 SBBI10
- Gene Names Orf:
- SBBI10
- Gene Names Primary:
- PRDX5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 214
- Sequence:
- MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.
Function
- Function:
- Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
- Catalytic Activity:
- 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
- Active Site:
- ACT_SITE 100 100 Cysteine sulfenic acid (-SOH) intermediate.
- Cross Reference Drug Bank:
- DB00995 DB03793
- Gene Ontology Go:
- cytoplasm
cytoplasmic vesicle
cytosol
extracellular exosome
extracellular space
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleus
perinuclear region of cytoplasm
peroxisomal matrix
peroxisome
antioxidant activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxidase activity
peroxiredoxin activity
peroxynitrite reductase activity
protein dimerization activity
receptor binding
RNA polymerase III regulatory region DNA binding
apoptotic process
cellular oxidant detoxification
cellular response to reactive oxygen species
gene expression
hydrogen peroxide catabolic process
inflammatory response
NADPH oxidation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of oxidoreductase activity
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
reactive nitrogen species metabolic process
regulation of apoptosis involved in tissue homeostasis
response to oxidative stress
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- apoptotic process
cellular oxidant detoxification
cellular response to reactive oxygen species
gene expression
hydrogen peroxide catabolic process
inflammatory response
NADPH oxidation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of oxidoreductase activity
negative regulation of transcription from RNA polymerase III promoter
positive regulation of collagen biosynthetic process
reactive nitrogen species metabolic process
regulation of apoptosis involved in tissue homeostasis
response to oxidative stress
response to reactive oxygen species
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- antioxidant activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxidase activity
peroxiredoxin activity
peroxynitrite reductase activity
protein dimerization activity
receptor binding
RNA polymerase III regulatory region DNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic vesicle
cytosol
extracellular exosome
extracellular space
intracellular membrane-bounded organelle
mitochondrial matrix
mitochondrion
nucleus
perinuclear region of cytoplasm
peroxisomal matrix
peroxisome - Keywords:
- 3D-structure
Acetylation
Alternative initiation
Alternative splicing
Antioxidant
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Mitochondrion
Oxidoreductase
Peroxidase
Peroxisome
Phosphoprotein
Polymorphism
Redox-active center
Reference proteome
Transit peptide