Names & Taxonomy
- Uniprot ID:
- P30043
- Entry Name:
- BLVRB_HUMAN
- Status:
- reviewed
- Protein Names:
- Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)
- Gene Names:
- BLVRB FLR
- Gene Names Primary:
- BLVRB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 206
- Sequence:
- MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
- Catalytic Activity:
- Reduced riboflavin + NADP(+) = riboflavin + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=36 uM for NADP
- Enzyme Regulation:
- ENZYME REGULATION: Mesobiliverdin acts as competitve inhibitor for flavin reduction, indicating that flavin and tetrapyrrole substrates compete for the same site.
- Cross Reference Drug Bank:
- DB00140
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
plasma membrane
biliverdin reductase activity
riboflavin reductase (NADPH) activity
heme catabolic process
porphyrin-containing compound metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- heme catabolic process
porphyrin-containing compound metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- biliverdin reductase activity
riboflavin reductase (NADPH) activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome