Names & Taxonomy

Uniprot ID:
P30043
Entry Name:
BLVRB_HUMAN
Status:
reviewed
Protein Names:
Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)
Gene Names:
BLVRB FLR
Gene Names Primary:
BLVRB
Organism:
Homo sapiens (Human)

Structure

Length:
206
Sequence:
MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
Catalytic Activity:
Reduced riboflavin + NADP(+) = riboflavin + NADPH.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=36 uM for NADP
Enzyme Regulation:
ENZYME REGULATION: Mesobiliverdin acts as competitve inhibitor for flavin reduction, indicating that flavin and tetrapyrrole substrates compete for the same site.
Cross Reference Drug Bank:
DB00140
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
plasma membrane
biliverdin reductase activity
riboflavin reductase (NADPH) activity
heme catabolic process
porphyrin-containing compound metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
heme catabolic process
porphyrin-containing compound metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
biliverdin reductase activity
riboflavin reductase (NADPH) activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
nucleoplasm
plasma membrane
Keywords:
3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
8117274 8799475 14702039 15057824 15489334 8280170 7929092 1286669 8313871 8687377 10620517 18241201 21269460 24275569 25944712 11224564