Names & Taxonomy
- Uniprot ID:
- P30041
- Entry Name:
- PRDX6_HUMAN
- Status:
- reviewed
- Protein Names:
- Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Liver 2D page spot 40) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (Red blood cells page spot 12)
- Gene Names:
- PRDX6 AOP2 KIAA0106
- Gene Names Primary:
- PRDX6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 224
- Sequence:
- MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
- Catalytic Activity:
- 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.; 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
- Active Site:
- ACT_SITE 32 32 For phospholipase activity.; ACT_SITE 47 47 Cysteine sulfenic acid (-SOH) intermediate.
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
cytosol
extracellular exosome
extracellular space
lysosome
membrane
glutathione peroxidase activity
hydrolase activity
peroxiredoxin activity
ubiquitin protein ligase binding
hydrogen peroxide catabolic process
lipid catabolic process
response to reactive oxygen species - Gene Ontology Biological Process:
- hydrogen peroxide catabolic process
lipid catabolic process
response to reactive oxygen species - Gene Ontology Molecular Function:
- glutathione peroxidase activity
hydrolase activity
peroxiredoxin activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
cytosol
extracellular exosome
extracellular space
lysosome
membrane - Keywords:
- 3D-structure
Acetylation
Antioxidant
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Hydrolase
Lipid degradation
Lipid metabolism
Lysosome
Multifunctional enzyme
Oxidoreductase
Peroxidase
Phosphoprotein
Redox-active center
Reference proteome - Interacts With:
- P29991; P09211; P54274