Names & Taxonomy
- Uniprot ID:
- P29597
- Entry Name:
- TYK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
- Gene Names:
- TYK2
- Gene Names Primary:
- TYK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1187
- Sequence:
- MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
- Proteomes:
- UP000005640
Function
- Function:
- Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 1023 1023 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytoskeleton
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
nucleus
ATP binding
growth hormone receptor binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
cell differentiation
cell migration
cytokine-mediated signaling pathway
innate immune response
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
protein phosphorylation
regulation of cell proliferation
regulation of type I interferon-mediated signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
type I interferon signaling pathway - Gene Ontology Biological Process:
- cell differentiation
cell migration
cytokine-mediated signaling pathway
innate immune response
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
protein phosphorylation
regulation of cell proliferation
regulation of type I interferon-mediated signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
type I interferon signaling pathway - Gene Ontology Molecular Function:
- ATP binding
growth hormone receptor binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoskeleton
cytosol
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
nucleus - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH2 domain
Transferase
Tyrosine-protein kinase - Interacts With:
- Q13643; Q6IBN1; P08238; Q5VWX1; Q6A162; Q9BUZ4