Names & Taxonomy
- Uniprot ID:
- P29508
- Entry Name:
- SPB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)
- Gene Names:
- SERPINB3 SCCA SCCA1
- Gene Names Primary:
- SERPINB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).
- Gene Ontology Go:
- cytoplasm
cytoplasmic vesicle
extracellular exosome
extracellular space
nucleus
vesicle
cysteine-type endopeptidase inhibitor activity
protease binding
serine-type endopeptidase inhibitor activity
virus receptor activity
autocrine signaling
negative regulation of catalytic activity
negative regulation of endopeptidase activity
negative regulation of JUN kinase activity
negative regulation of peptidase activity
negative regulation of proteolysis
paracrine signaling
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endopeptidase activity
positive regulation of epithelial to mesenchymal transition
viral entry into host cell - Gene Ontology Biological Process:
- autocrine signaling
negative regulation of catalytic activity
negative regulation of endopeptidase activity
negative regulation of JUN kinase activity
negative regulation of peptidase activity
negative regulation of proteolysis
paracrine signaling
positive regulation of cell migration
positive regulation of cell proliferation
positive regulation of endopeptidase activity
positive regulation of epithelial to mesenchymal transition
viral entry into host cell - Gene Ontology Molecular Function:
- cysteine-type endopeptidase inhibitor activity
protease binding
serine-type endopeptidase inhibitor activity
virus receptor activity - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic vesicle
extracellular exosome
extracellular space
nucleus
vesicle - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor