Names & Taxonomy
- Uniprot ID:
- P29466
- Entry Name:
- CASP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
- Gene Names:
- CASP1 IL1BC IL1BCE
- Gene Names Primary:
- CASP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 404
- Sequence:
- MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
- Catalytic Activity:
- Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
- Enzyme Regulation:
- ENZYME REGULATION: Specifically inhibited by the cowpox virus Crma protein.
- Active Site:
- ACT_SITE 237 237
- Cross Reference Drug Bank:
- DB01017
- Gene Ontology Go:
- AIM2 inflammasome complex
cytosol
extracellular region
IPAF inflammasome complex
mitochondrion
NLRP1 inflammasome complex
NLRP3 inflammasome complex
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
endopeptidase activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic process
cellular response to mechanical stimulus
cellular response to organic substance
innate immune response
interleukin-1 beta production
membrane hyperpolarization
mitochondrial depolarization
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
programmed necrotic cell death
proteolysis
pyroptosis
regulation of autophagy
response to ATP
response to hypoxia
response to lipopolysaccharide
signal transduction
toxin transport - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic process
cellular response to mechanical stimulus
cellular response to organic substance
innate immune response
interleukin-1 beta production
membrane hyperpolarization
mitochondrial depolarization
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
programmed necrotic cell death
proteolysis
pyroptosis
regulation of autophagy
response to ATP
response to hypoxia
response to lipopolysaccharide
signal transduction
toxin transport - Gene Ontology Molecular Function:
- cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
endopeptidase activity - Gene Ontology Cellular Component:
- AIM2 inflammasome complex
cytosol
extracellular region
IPAF inflammasome complex
mitochondrion
NLRP1 inflammasome complex
NLRP3 inflammasome complex - Keywords:
- 3D-structure
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Phosphoprotein
Polymorphism
Protease
Reference proteome
Thiol protease
Zymogen - Interacts With:
- P09038; P01583; Q9NPP4; Q9ULZ3; Q08AM6