Names & Taxonomy
- Uniprot ID:
- P29376
- Entry Name:
- LTK_HUMAN
- Status:
- reviewed
- Protein Names:
- Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
- Gene Names:
- LTK TYK1
- Gene Names Primary:
- LTK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 864
- Sequence:
- MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 643 643 Proton acceptor.
- Gene Ontology Go:
- integral component of plasma membrane
intracellular
membrane
plasma membrane
ATP binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
cell proliferation
cellular response to retinoic acid
negative regulation of apoptotic process
peptidyl-tyrosine phosphorylation
phosphatidylinositol 3-kinase signaling
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Biological Process:
- cell proliferation
cellular response to retinoic acid
negative regulation of apoptotic process
peptidyl-tyrosine phosphorylation
phosphatidylinositol 3-kinase signaling
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway - Gene Ontology Molecular Function:
- ATP binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
intracellular
membrane
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Glycoprotein
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Systemic lupus erythematosus
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase