Names & Taxonomy
- Uniprot ID:
- P29373
- Entry Name:
- RABP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)
- Gene Names:
- CRABP2
- Gene Names Primary:
- CRABP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 138
- Sequence:
- MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Function
- Function:
- Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
- Cross Reference Drug Bank:
- DB00523 DB00755
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
nucleoplasm
retinal binding
retinoic acid binding
retinoid binding
retinol binding
transporter activity
embryonic forelimb morphogenesis
epidermis development
positive regulation of collateral sprouting
regulation of retinoic acid receptor signaling pathway
regulation of transcription, DNA-templated
retinoic acid metabolic process
signal transduction - Gene Ontology Biological Process:
- embryonic forelimb morphogenesis
epidermis development
positive regulation of collateral sprouting
regulation of retinoic acid receptor signaling pathway
regulation of transcription, DNA-templated
retinoic acid metabolic process
signal transduction - Gene Ontology Molecular Function:
- retinal binding
retinoic acid binding
retinoid binding
retinol binding
transporter activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
nucleoplasm - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Endoplasmic reticulum
Isopeptide bond
Nucleus
Reference proteome
Retinol-binding
Transport
Ubl conjugation
Vitamin A - Interacts With:
- Q8N6L0