Names & Taxonomy
- Uniprot ID:
- P29320
- Entry Name:
- EPHA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
- Gene Names:
- EPHA3 ETK ETK1 HEK TYRO4
- Gene Names Primary:
- EPHA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 983
- Sequence:
- MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 746 746 Proton acceptor.
- Gene Ontology Go:
- early endosome
extracellular region
integral component of plasma membrane
plasma membrane
ATP binding
GPI-linked ephrin receptor activity
axon guidance
cell adhesion
cell migration
cellular response to retinoic acid
ephrin receptor signaling pathway
fasciculation of motor neuron axon
fasciculation of sensory neuron axon
positive regulation of neuron projection development
regulation of actin cytoskeleton organization
regulation of epithelial to mesenchymal transition
regulation of focal adhesion assembly
regulation of GTPase activity
regulation of microtubule cytoskeleton organization - Gene Ontology Biological Process:
- axon guidance
cell adhesion
cell migration
cellular response to retinoic acid
ephrin receptor signaling pathway
fasciculation of motor neuron axon
fasciculation of sensory neuron axon
positive regulation of neuron projection development
regulation of actin cytoskeleton organization
regulation of epithelial to mesenchymal transition
regulation of focal adhesion assembly
regulation of GTPase activity
regulation of microtubule cytoskeleton organization - Gene Ontology Molecular Function:
- ATP binding
GPI-linked ephrin receptor activity - Gene Ontology Cellular Component:
- early endosome
extracellular region
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Glycoprotein
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase