Names & Taxonomy

Uniprot ID:
P29218
Entry Name:
IMPA1_HUMAN
Status:
reviewed
Protein Names:
Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)
Gene Names:
IMPA1 IMPA
Gene Names Primary:
IMPA1
Organism:
Homo sapiens (Human)

Structure

Length:
277
Sequence:
MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Pathway:
Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Catalytic Activity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=42 uM for D-myo-inositol 1-phosphate
Enzyme Regulation:
ENZYME REGULATION: Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
Cross Reference Drug Bank:
DB01356
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
identical protein binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
lithium ion binding
magnesium ion binding
manganese ion binding
protein homodimerization activity
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process
Gene Ontology Biological Process:
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process
Gene Ontology Molecular Function:
identical protein binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
lithium ion binding
magnesium ion binding
manganese ion binding
protein homodimerization activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Lithium
Magnesium
Metal-binding
Polymorphism
Reference proteome
Interacts With:
Itself; O14732

Publication

PubMed ID:
1377913 9339367 14702039 16421571 15489334 9462881 17068342 18669648 19690332 21269460 1332026 8068620 8068621 8718889 23027737