Names & Taxonomy
- Uniprot ID:
- P29218
- Entry Name:
- IMPA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)
- Gene Names:
- IMPA1 IMPA
- Gene Names Primary:
- IMPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 277
- Sequence:
- MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
- Pathway:
- Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
- Catalytic Activity:
- Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=42 uM for D-myo-inositol 1-phosphate
- Enzyme Regulation:
- ENZYME REGULATION: Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
- Cross Reference Drug Bank:
- DB01356
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
identical protein binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
lithium ion binding
magnesium ion binding
manganese ion binding
protein homodimerization activity
inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- inositol biosynthetic process
inositol metabolic process
inositol phosphate dephosphorylation
inositol phosphate metabolic process
phosphate-containing compound metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- identical protein binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
lithium ion binding
magnesium ion binding
manganese ion binding
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Lithium
Magnesium
Metal-binding
Polymorphism
Reference proteome - Interacts With:
- Itself; O14732