Names & Taxonomy

Uniprot ID:
P28845
Entry Name:
DHI1_HUMAN
Status:
reviewed
Protein Names:
Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1)
Gene Names:
HSD11B1 HSD11 HSD11L SDR26C1
Gene Names Primary:
HSD11B1
Organism:
Homo sapiens (Human)

Structure

Length:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Catalytic Activity:
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
Active Site:
ACT_SITE 183 183 Proton acceptor.
Cross Reference Drug Bank:
DB00635
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
membrane
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
11-beta-hydroxysteroid dehydrogenase activity
glucocorticoid biosynthetic process
lung development
small molecule metabolic process
steroid metabolic process
Gene Ontology Biological Process:
glucocorticoid biosynthetic process
lung development
small molecule metabolic process
steroid metabolic process
Gene Ontology Molecular Function:
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
11-beta-hydroxysteroid dehydrogenase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
membrane
Keywords:
3D-structure
Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid metabolism
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Signal-anchor
Steroid metabolism
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1885595 12414862 14702039 16710414 15489334 10497248 12858176 15152005 19159218 24275569 15513927 17070044 17919905 18485702 18069989 18553955 19217779 16959974