Names & Taxonomy
- Uniprot ID:
- P28845
- Entry Name:
- DHI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1)
- Gene Names:
- HSD11B1 HSD11 HSD11L SDR26C1
- Gene Names Primary:
- HSD11B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 292
- Sequence:
- MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
- Catalytic Activity:
- An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
- Active Site:
- ACT_SITE 183 183 Proton acceptor.
- Cross Reference Drug Bank:
- DB00635
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
11-beta-hydroxysteroid dehydrogenase activity
glucocorticoid biosynthetic process
lung development
small molecule metabolic process
steroid metabolic process - Gene Ontology Biological Process:
- glucocorticoid biosynthetic process
lung development
small molecule metabolic process
steroid metabolic process - Gene Ontology Molecular Function:
- 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
11-beta-hydroxysteroid dehydrogenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- 3D-structure
Complete proteome
Endoplasmic reticulum
Glycoprotein
Lipid metabolism
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Signal-anchor
Steroid metabolism
Transmembrane
Transmembrane helix