Names & Taxonomy
- Uniprot ID:
- P28221
- Entry Name:
- 5HT1D_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)
- Gene Names:
- HTR1D HTR1DA HTRL
- Gene Names Primary:
- HTR1D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 377
- Sequence:
- MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
- Cross Reference Drug Bank:
- DB00918 DB00321 DB00714 DB01238 DB01200 DB00248 DB00363 DB00320 DB00216 DB01049 DB00696 DB00998 DB01221 DB00589 DB00408 DB00952 DB00334 DB01267 DB01186 DB00413 DB01224 DB00734 DB00953 DB00268 DB00669 DB00726 DB01392 DB00246 DB00315
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled serotonin receptor activity
serotonin binding
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
intestine smooth muscle contraction
regulation of behavior
regulation of locomotion
response to toxic substance
serotonin receptor signaling pathway
synaptic transmission
vasoconstriction - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
intestine smooth muscle contraction
regulation of behavior
regulation of locomotion
response to toxic substance
serotonin receptor signaling pathway
synaptic transmission
vasoconstriction - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
serotonin binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix