Names & Taxonomy
- Uniprot ID:
- P27986
- Entry Name:
- P85A_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
- Gene Names:
- PIK3R1 GRB1
- Gene Names Primary:
- PIK3R1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
- Proteomes:
- UP000005640
Function
- Function:
- Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
- Cross Reference Drug Bank:
- DB01064
- Gene Ontology Go:
- cell-cell junction
cis-Golgi network
cytoplasm
cytosol
membrane
nucleus
perinuclear endoplasmic reticulum membrane
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
plasma membrane
1-phosphatidylinositol-3-kinase regulator activity
ErbB-3 class receptor binding
insulin binding
insulin receptor binding
insulin receptor substrate binding
insulin-like growth factor receptor binding
neurotrophin TRKA receptor binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol 3-kinase regulator activity
protein phosphatase binding
transcription factor binding
transmembrane receptor protein tyrosine kinase adaptor activity
B cell differentiation
blood coagulation
cellular glucose homeostasis
cellular response to insulin stimulus
cellular response to UV
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
growth hormone receptor signaling pathway
innate immune response
insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
leukocyte migration
negative regulation of apoptotic process
negative regulation of cell-matrix adhesion
negative regulation of osteoclast differentiation
neurotrophin TRK receptor signaling pathway
NFAT protein import into nucleus
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
phospholipid metabolic process
platelet activation
positive regulation of cell migration
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of establishment of protein localization to plasma membrane
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of RNA splicing
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
protein phosphorylation
protein stabilization
regulation of phosphatidylinositol 3-kinase activity
regulation of stress fiber assembly
response to endoplasmic reticulum stress
small molecule metabolic process
T cell costimulation
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Biological Process:
- B cell differentiation
blood coagulation
cellular glucose homeostasis
cellular response to insulin stimulus
cellular response to UV
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
fibroblast growth factor receptor signaling pathway
growth hormone receptor signaling pathway
innate immune response
insulin-like growth factor receptor signaling pathway
insulin receptor signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
leukocyte migration
negative regulation of apoptotic process
negative regulation of cell-matrix adhesion
negative regulation of osteoclast differentiation
neurotrophin TRK receptor signaling pathway
NFAT protein import into nucleus
phosphatidylinositol 3-kinase signaling
phosphatidylinositol biosynthetic process
phosphatidylinositol-mediated signaling
phosphatidylinositol phosphorylation
phospholipid metabolic process
platelet activation
positive regulation of cell migration
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of establishment of protein localization to plasma membrane
positive regulation of glucose import
positive regulation of glucose import in response to insulin stimulus
positive regulation of RNA splicing
positive regulation of transcription factor import into nucleus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
protein phosphorylation
protein stabilization
regulation of phosphatidylinositol 3-kinase activity
regulation of stress fiber assembly
response to endoplasmic reticulum stress
small molecule metabolic process
T cell costimulation
T cell receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Molecular Function:
- 1-phosphatidylinositol-3-kinase regulator activity
ErbB-3 class receptor binding
insulin binding
insulin-like growth factor receptor binding
insulin receptor binding
insulin receptor substrate binding
neurotrophin TRKA receptor binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol 3-kinase regulator activity
protein phosphatase binding
transcription factor binding
transmembrane receptor protein tyrosine kinase adaptor activity - Gene Ontology Cellular Component:
- cell-cell junction
cis-Golgi network
cytoplasm
cytosol
membrane
nucleus
perinuclear endoplasmic reticulum membrane
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Dwarfism
Host-virus interaction
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Repeat
SH2 domain
SH3 domain
Stress response
Transport
Ubl conjugation - Interacts With:
- Q8IZP0; P42684; P10275; P22681; P10747; Q13111; Q8IY22; P46108; P46109; P16410; Q9Y2H0; P00533; P41970; P04626; P21860; P03372; P48023; P11362; P17948; P36888; Q13480; P62993; P42858; P08069; P06213; P35568; P35570; Q9Y4H2; P10721; Q86VI4-3; O43561; Q92918; P45983; P08581; Q8WX92; P03496; Q6PFX7; Q8BM65-4; P09619; P42336; P42338; P16885; P49023; Q13905; P26373; P19793; Q9NP31; Q9UPX8; P29353; Q96EB6; Q07889; P12931; P30874; P58753; O15455; Q15661; Q9ULW0; Q9UKW4; Q99152; Q8IUH5
Publication
- PubMed ID:
- 1849461 8628286 14702039 15372022 15489334 7692233 8276809 7518429 7541045 7537849 8940081 9038210 9178760 9489702 9553137 9687533 10528161 10086340 10739672 10867024 11087752 11526404 11912194 12359715 12009866 12186904 15488758 15526160 15302586 15561106 15592455 18348712 18721752 19807924 19286672 15863030 19369195 19690332 20348923 21228233 22351933 22814378 23810382 23192871 23676467 25133428 25944712 8648629 8599763 8962058 11567151 7681364 8961927 8670861 17626883 18079394 19805105 19919182 9032108 10768093 23810378 23810379