Names & Taxonomy
- Uniprot ID:
- P27707
- Entry Name:
- DCK_HUMAN
- Status:
- reviewed
- Protein Names:
- Deoxycytidine kinase (dCK) (EC 2.7.1.74)
- Gene Names:
- DCK
- Gene Names Primary:
- DCK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 260
- Sequence:
- MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
- Catalytic Activity:
- NTP + deoxycytidine = NDP + dCMP.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC)
- Active Site:
- ACT_SITE 127 127 Proton acceptor.
- Cross Reference Drug Bank:
- DB00242 DB00631 DB00987 DB01262 DB00879 DB01073 DB00441 DB00709 DB01280 DB00642 DB00943
- Gene Ontology Go:
- cytosol
nucleus
ATP binding
deoxycytidine kinase activity
drug binding
nucleoside kinase activity
protein homodimerization activity
deoxyribonucleoside monophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
purine nucleobase metabolic process
purine-containing compound salvage
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
pyrimidine nucleotide metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- deoxyribonucleoside monophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
purine-containing compound salvage
purine nucleobase metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
pyrimidine nucleotide metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ATP binding
deoxycytidine kinase activity
drug binding
nucleoside kinase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
nucleus - Keywords:
- 3D-structure
ATP-binding
Complete proteome
Direct protein sequencing
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Transferase