Names & Taxonomy
- Uniprot ID:
- P27169
- Entry Name:
- PON1_HUMAN
- Status:
- reviewed
- Protein Names:
- Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
- Gene Names:
- PON1 PON
- Gene Names Primary:
- PON1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 355
- Sequence:
- MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
- Catalytic Activity:
- A phenyl acetate + H(2)O = a phenol + acetate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 2 calcium ions per subunit.;
- Active Site:
- ACT_SITE 115 115 Proton acceptor.
- Cross Reference Drug Bank:
- DB01327
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular region
extracellular space
high-density lipoprotein particle
intracellular membrane-bounded organelle
spherical high-density lipoprotein particle
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
calcium ion binding
phospholipid binding
protein homodimerization activity
aromatic compound catabolic process
carboxylic acid catabolic process
cholesterol metabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
positive regulation of cholesterol efflux
positive regulation of transporter activity
response to external stimulus
response to fatty acid
response to fluoride
response to nutrient levels
response to toxic substance - Gene Ontology Biological Process:
- aromatic compound catabolic process
carboxylic acid catabolic process
cholesterol metabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
positive regulation of cholesterol efflux
positive regulation of transporter activity
response to external stimulus
response to fatty acid
response to fluoride
response to nutrient levels
response to toxic substance - Gene Ontology Molecular Function:
- acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
calcium ion binding
phospholipid binding
protein homodimerization activity - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular region
extracellular space
high-density lipoprotein particle
intracellular membrane-bounded organelle
spherical high-density lipoprotein particle - Keywords:
- 3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
HDL
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal