Names & Taxonomy

Uniprot ID:
P27169
Entry Name:
PON1_HUMAN
Status:
reviewed
Protein Names:
Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
Gene Names:
PON1 PON
Gene Names Primary:
PON1
Organism:
Homo sapiens (Human)

Structure

Length:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space.

Function

Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Catalytic Activity:
A phenyl acetate + H(2)O = a phenol + acetate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 2 calcium ions per subunit.;
Active Site:
ACT_SITE 115 115 Proton acceptor.
Cross Reference Drug Bank:
DB01327
Gene Ontology Go:
blood microparticle
extracellular exosome
extracellular region
extracellular space
high-density lipoprotein particle
intracellular membrane-bounded organelle
spherical high-density lipoprotein particle
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
calcium ion binding
phospholipid binding
protein homodimerization activity
aromatic compound catabolic process
carboxylic acid catabolic process
cholesterol metabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
positive regulation of cholesterol efflux
positive regulation of transporter activity
response to external stimulus
response to fatty acid
response to fluoride
response to nutrient levels
response to toxic substance
Gene Ontology Biological Process:
aromatic compound catabolic process
carboxylic acid catabolic process
cholesterol metabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
positive regulation of cholesterol efflux
positive regulation of transporter activity
response to external stimulus
response to fatty acid
response to fluoride
response to nutrient levels
response to toxic substance
Gene Ontology Molecular Function:
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
calcium ion binding
phospholipid binding
protein homodimerization activity
Gene Ontology Cellular Component:
blood microparticle
extracellular exosome
extracellular region
extracellular space
high-density lipoprotein particle
intracellular membrane-bounded organelle
spherical high-density lipoprotein particle
Keywords:
3D-structure
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
HDL
Hydrolase
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
1657140 7916578 8393742 8393745 8812495 9261565 14702039 12853948 12690205 15489334 8382160 8292612 1718413 1673382 7638166 10479665 14760718 15772423 16335952 16531243 19159218 24275569 15098021 8098250 9661650 12783936 18987736