Names & Taxonomy
- Uniprot ID:
- P26639
- Entry Name:
- SYTC_HUMAN
- Status:
- reviewed
- Protein Names:
- Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)
- Gene Names:
- TARS
- Gene Names Primary:
- TARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 723
- Sequence:
- MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEMYNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIAKVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRILNEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Catalytic Activity:
- ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
- Cross Reference Drug Bank:
- DB00156
- Gene Ontology Go:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
ATP binding
protein homodimerization activity
threonine-tRNA ligase activity
gene expression
threonyl-tRNA aminoacylation
translation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
threonyl-tRNA aminoacylation
translation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
protein homodimerization activity
threonine-tRNA ligase activity - Gene Ontology Cellular Component:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Isopeptide bond
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Ubl conjugation - Interacts With:
- Q9BPX7; A2RTX5