Names & Taxonomy
- Uniprot ID:
- P26572
- Entry Name:
- MGAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)
- Gene Names:
- MGAT1 GGNT1 GLCT1 GLYT1 MGAT
- Gene Names Primary:
- MGAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane; Single-pass type II membrane protein.
Function
- Function:
- Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Active Site:
- ACT_SITE 289 289 Proton acceptor.
- Gene Ontology Go:
- extracellular exosome
extracellular vesicle
Golgi membrane
integral component of membrane
membrane
acetylglucosaminyltransferase activity
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding
carbohydrate metabolic process
cellular protein metabolic process
in utero embryonic development
post-translational protein modification
protein glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine catabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular protein metabolic process
in utero embryonic development
post-translational protein modification
protein glycosylation
protein N-linked glycosylation via asparagine
UDP-N-acetylglucosamine catabolic process - Gene Ontology Molecular Function:
- acetylglucosaminyltransferase activity
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
metal ion binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular vesicle
Golgi membrane
integral component of membrane
membrane - Keywords:
- Complete proteome
Disulfide bond
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix