Names & Taxonomy
- Uniprot ID:
- P25963
- Entry Name:
- IKBA_HUMAN
- Status:
- reviewed
- Protein Names:
- NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
- Gene Names:
- NFKBIA IKBA MAD3 NFKBI
- Gene Names Primary:
- NFKBIA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Function
- Function:
- Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
- Cross Reference Drug Bank:
- DB00945
- Gene Ontology Go:
- cytoplasm
cytosol
I-kappaB/NF-kappaB complex
nucleus
plasma membrane
enzyme binding
identical protein binding
NF-kappaB binding
nuclear localization sequence binding
transcription factor binding
ubiquitin protein ligase binding
apoptotic process
cellular response to cold
cellular response to cytokine stimulus
cellular response to organic cyclic compound
cytoplasmic sequestering of NF-kappaB
cytoplasmic sequestering of transcription factor
Fc-epsilon receptor signaling pathway
innate immune response
lipopolysaccharide-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of lipid storage
negative regulation of macrophage derived foam cell differentiation
negative regulation of myeloid cell differentiation
negative regulation of NF-kappaB transcription factor activity
negative regulation of Notch signaling pathway
neurotrophin TRK receptor signaling pathway
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
positive regulation of cellular protein metabolic process
positive regulation of cholesterol efflux
positive regulation of NF-kappaB transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon production
protein import into nucleus, translocation
regulation of cell proliferation
regulation of NF-kappaB import into nucleus
response to exogenous dsRNA
response to muramyl dipeptide
response to muscle stretch
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
viral process - Gene Ontology Biological Process:
- apoptotic process
cellular response to cold
cellular response to cytokine stimulus
cellular response to organic cyclic compound
cytoplasmic sequestering of NF-kappaB
cytoplasmic sequestering of transcription factor
Fc-epsilon receptor signaling pathway
innate immune response
lipopolysaccharide-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of lipid storage
negative regulation of macrophage derived foam cell differentiation
negative regulation of myeloid cell differentiation
negative regulation of NF-kappaB transcription factor activity
negative regulation of Notch signaling pathway
neurotrophin TRK receptor signaling pathway
nucleotide-binding oligomerization domain containing 1 signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
positive regulation of cellular protein metabolic process
positive regulation of cholesterol efflux
positive regulation of NF-kappaB transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of type I interferon production
protein import into nucleus, translocation
regulation of cell proliferation
regulation of NF-kappaB import into nucleus
response to exogenous dsRNA
response to muramyl dipeptide
response to muscle stretch
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
viral process - Gene Ontology Molecular Function:
- enzyme binding
identical protein binding
NF-kappaB binding
nuclear localization sequence binding
transcription factor binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
I-kappaB/NF-kappaB complex
nucleus
plasma membrane - Keywords:
- 3D-structure
ANK repeat
Complete proteome
Cytoplasm
Disease mutation
Ectodermal dysplasia
Host-virus interaction
Hydroxylation
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation - Interacts With:
- Itself; P14340; Q9E7P0; O15111; Q60680-2; Q8N668; O14920; Q9Y6K9; Q14511; P19838; Q04864; Q04206; P23396; P0CG48; Q9J0X9