Names & Taxonomy

Uniprot ID:
P25929
Entry Name:
NPY1R_HUMAN
Status:
reviewed
Protein Names:
Neuropeptide Y receptor type 1 (NPY1-R)
Gene Names:
NPY1R NPYR NPYY1
Gene Names Primary:
NPY1R
Organism:
Homo sapiens (Human)

Structure

Length:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > PYY, PYY and NPY > NPY (2-36) > PP and PYY (3-36) > PP > NPY free acid.
Gene Ontology Go:
axon
cytosol
integral component of plasma membrane
plasma membrane
synaptic vesicle
neuropeptide Y receptor activity
pancreatic polypeptide receptor activity
peptide YY receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood circulation
cell surface receptor signaling pathway
feeding behavior
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
glucose metabolic process
locomotory behavior
negative regulation of cytosolic calcium ion concentration
negative regulation of hormone secretion
outflow tract morphogenesis
peristalsis
positive regulation of vasoconstriction
regulation of blood pressure
regulation of multicellular organism growth
response to estradiol
sensory perception of pain
Gene Ontology Biological Process:
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
blood circulation
cell surface receptor signaling pathway
feeding behavior
glucose metabolic process
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
locomotory behavior
negative regulation of cytosolic calcium ion concentration
negative regulation of hormone secretion
outflow tract morphogenesis
peristalsis
positive regulation of vasoconstriction
regulation of blood pressure
regulation of multicellular organism growth
response to estradiol
sensory perception of pain
Gene Ontology Molecular Function:
neuropeptide Y receptor activity
pancreatic polypeptide receptor activity
peptide YY receptor activity
Gene Ontology Cellular Component:
axon
cytosol
integral component of plasma membrane
plasma membrane
synaptic vesicle
Keywords:
3D-structure
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P10082

Publication

PubMed ID:
1317848 1321422 8095935 14702039 15489334