Names & Taxonomy
- Uniprot ID:
- P25788
- Entry Name:
- PSA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Proteasome subunit alpha type-3 (EC 3.4.25.1) (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
- Gene Names:
- PSMA3 HC8 PSC8
- Gene Names Primary:
- PSMA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 255
- Sequence:
- MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus.
Function
- Function:
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
- Catalytic Activity:
- Cleavage of peptide bonds with very broad specificity.
- Cross Reference Drug Bank:
- DB00188
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus
proteasome complex
proteasome core complex
proteasome core complex, alpha-subunit complex
threonine-type endopeptidase activity
activation of MAPKK activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
axon guidance
cellular nitrogen compound metabolic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
gene expression
innate immune response
insulin receptor signaling pathway
MAPK cascade
mitotic cell cycle
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
neurotrophin TRK receptor signaling pathway
NIK/NF-kappaB signaling
polyamine metabolic process
positive regulation of canonical Wnt signaling pathway
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
programmed cell death
protein polyubiquitination
Ras protein signal transduction
regulation of apoptotic process
regulation of cellular amino acid metabolic process
regulation of endopeptidase activity
regulation of mRNA stability
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Biological Process:
- activation of MAPKK activity
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
axon guidance
cellular nitrogen compound metabolic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G1/S transition of mitotic cell cycle
gene expression
innate immune response
insulin receptor signaling pathway
MAPK cascade
mitotic cell cycle
negative regulation of apoptotic process
negative regulation of canonical Wnt signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
neurotrophin TRK receptor signaling pathway
NIK/NF-kappaB signaling
polyamine metabolic process
positive regulation of canonical Wnt signaling pathway
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
programmed cell death
protein polyubiquitination
Ras protein signal transduction
regulation of apoptotic process
regulation of cellular amino acid metabolic process
regulation of endopeptidase activity
regulation of mRNA stability
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
T cell receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Molecular Function:
- threonine-type endopeptidase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
nucleus
proteasome complex
proteasome core complex
proteasome core complex, alpha-subunit complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Protease
Proteasome
Reference proteome
Threonine protease - Interacts With:
- B2R550; Q5JPT6; Q5W150; Q7KZQ1; Q9H8E5; Q9HAA0; Q9NWL9; P27449; Q8WVV5; Q7Z3D6; O95561; Q58A44; Q96CW7; A2RU00; Q9NRJ3; Q9BUF7; P09228; O15320; Q14565; Q9NQL9; Q9BTL3; Q8N0U1; Q96MZ4; Q96D16; Q9Y3I1; P23769; P23771; Q9H8Y8; Q8N779; A0A024R5S0; Q6IPM2; Q6UWL6; Q8N7Y1; Q3LI72; Q6PEX3; Q8IUC2; Q14847; O95202; Q00987; Q9H6H2; P48146; P16860; Q8N2R0; Q86TB9; P29590; Q14CW7; Q9NZ81; P79522; P25786; P25789; P60900; O14818; P28070; Q9H3S7; Q6NUJ5; Q8TBN0; Q9Y4B4; O43251; Q9BTD8; Q14D33; Q66K80; Q15637; Q8ND83; Q7L9D0; P14678-2; Q5TAL4; Q6RVD6; Q12846; O43752; Q96HZ7; A5D8V6; Q8N895; Q66K41
Publication
- PubMed ID:
- 2025653 14702039 15489334 7811265 11521686 11350925 12376572 12472671 14550573 14674694 15831937 16337594 15592455 17081983 16298756 16964243 17323924 17487921 17499743 19367720 18669648 18318008 19413330 18971267 19690332 19608861 20068231 21269460 21406692 22223895 22814378 24275569 26524591