Names & Taxonomy
- Uniprot ID:
- P25103
- Entry Name:
- NK1R_HUMAN
- Status:
- reviewed
- Protein Names:
- Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
- Gene Names:
- TACR1 NK1R TAC1R
- Gene Names Primary:
- TACR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 407
- Sequence:
- MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
- Cross Reference Drug Bank:
- DB00673 DB01221 DB09048 DB04894
- Gene Ontology Go:
- cell body
cell surface
cytosol
dendrite
integral component of plasma membrane
plasma membrane
substance P receptor activity
tachykinin receptor activity
acute inflammatory response
aggressive behavior
angiotensin-mediated drinking behavior
associative learning
behavioral response to pain
cell surface receptor signaling pathway
detection of abiotic stimulus
eating behavior
inflammatory response
long-term memory
operant conditioning
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of action potential
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of epithelial cell migration
positive regulation of epithelial cell proliferation
positive regulation of hormone secretion
positive regulation of leukocyte migration
positive regulation of lymphocyte proliferation
positive regulation of ossification
positive regulation of renal sodium excretion
positive regulation of saliva secretion
positive regulation of smooth muscle contraction
positive regulation of stress fiber assembly
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
positive regulation of uterine smooth muscle contraction
positive regulation of vascular permeability
positive regulation of vasoconstriction
regulation of smooth muscle cell migration
regulation of smooth muscle cell proliferation
response to auditory stimulus
response to electrical stimulus
response to estradiol
response to ethanol
response to heat
response to morphine
response to nicotine
response to ozone
response to progesterone
sensory perception of pain
smooth muscle contraction involved in micturition
sperm ejaculation
tachykinin receptor signaling pathway - Gene Ontology Biological Process:
- acute inflammatory response
aggressive behavior
angiotensin-mediated drinking behavior
associative learning
behavioral response to pain
cell surface receptor signaling pathway
detection of abiotic stimulus
eating behavior
inflammatory response
long-term memory
operant conditioning
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of action potential
positive regulation of blood pressure
positive regulation of cytosolic calcium ion concentration
positive regulation of epithelial cell migration
positive regulation of epithelial cell proliferation
positive regulation of hormone secretion
positive regulation of leukocyte migration
positive regulation of lymphocyte proliferation
positive regulation of ossification
positive regulation of renal sodium excretion
positive regulation of saliva secretion
positive regulation of smooth muscle contraction
positive regulation of stress fiber assembly
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
positive regulation of uterine smooth muscle contraction
positive regulation of vascular permeability
positive regulation of vasoconstriction
regulation of smooth muscle cell migration
regulation of smooth muscle cell proliferation
response to auditory stimulus
response to electrical stimulus
response to estradiol
response to ethanol
response to heat
response to morphine
response to nicotine
response to ozone
response to progesterone
sensory perception of pain
smooth muscle contraction involved in micturition
sperm ejaculation
tachykinin receptor signaling pathway - Gene Ontology Molecular Function:
- substance P receptor activity
tachykinin receptor activity - Gene Ontology Cellular Component:
- cell body
cell surface
cytosol
dendrite
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P20366