Names & Taxonomy
- Uniprot ID:
- P25092
- Entry Name:
- GUC2C_HUMAN
- Status:
- reviewed
- Protein Names:
- Heat-stable enterotoxin receptor (STA receptor) (hSTAR) (EC 4.6.1.2) (Guanylyl cyclase C) (GC-C) (Intestinal guanylate cyclase)
- Gene Names:
- GUCY2C GUC2C STAR
- Gene Names Primary:
- GUCY2C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1073
- Sequence:
- MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
- Catalytic Activity:
- GTP = 3',5'-cyclic GMP + diphosphate.
- Cross Reference Drug Bank:
- DB08890
- Gene Ontology Go:
- endoplasmic reticulum membrane
guanylate cyclase complex, soluble
integral component of membrane
plasma membrane
ATP binding
GTP binding
guanylate cyclase activity
protein kinase activity
toxic substance binding
intracellular signal transduction
receptor guanylyl cyclase signaling pathway
regulation of cell proliferation
response to toxic substance - Gene Ontology Biological Process:
- intracellular signal transduction
receptor guanylyl cyclase signaling pathway
regulation of cell proliferation
response to toxic substance - Gene Ontology Molecular Function:
- ATP binding
GTP binding
guanylate cyclase activity
protein kinase activity
toxic substance binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
guanylate cyclase complex, soluble
integral component of membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Endoplasmic reticulum
GTP-binding
Glycoprotein
Lyase
Membrane
Nucleotide-binding
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
cGMP biosynthesis - Interacts With:
- Q86UT5-2