Names & Taxonomy
- Uniprot ID:
- P24462
- Entry Name:
- CP3A7_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (Cytochrome P450-HFLA)
- Gene Names:
- CYP3A7
- Gene Names Primary:
- CYP3A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 503
- Sequence:
- MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00802 DB00404 DB01424 DB01118 DB00381 DB00673 DB01238 DB00637 DB01076 DB00921 DB00490 DB00201 DB00564 DB00446 DB01114 DB01166 DB00501 DB00537 DB00604 DB01211 DB00257 DB05239 DB00907 DB00318 DB00531 DB00091 DB09102 DB00250 DB00705 DB01234 DB00514 DB00647 DB00829 DB00343 DB01248 DB08930 DB01184 DB00700 DB00199 DB00783 DB00593 DB01466 DB01023 DB00813 DB01216 DB00196 DB00588 DB00176 DB06730 DB00502 DB00741 DB01181 DB04946 DB00619 DB00458 DB00224 DB00762 DB01167 DB01026 DB00528 DB01227 DB00281 DB00227 DB00333 DB00683 DB00834 DB00731 DB01149 DB00220 DB01115 DB00401 DB01054 DB00717 DB01059 DB00904 DB00842 DB00497 DB01229 DB00780 DB01174 DB00252 DB01100 DB01058 DB00396 DB00571 DB01224 DB00908 DB00468 DB01045 DB01201 DB00734 DB00503 DB00938 DB01232 DB00203 DB00641 DB00877 DB00398 DB01268 DB00864 DB00675 DB00976 DB06287 DB00624 DB00656 DB00755 DB00897 DB00661 DB00541 DB00582 DB00943 DB00962 DB00246 DB00425
- Gene Ontology Go:
- endoplasmic reticulum membrane
aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxygen binding
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aromatase activity
heme binding
iron ion binding
monooxygenase activity
oxygen binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome